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Using a canine model of extensive resection of the pancreas and total pancreatectomy with/without postoperative insulin administration, the authors determined glucose, lipoprotein (LP) fraction, triglyceride (TG), free fatty acid (FFA) and post heparin lipolytic activity (PHLA) in the blood.In these groups of total pancreatectomy without postoperative insulin administration and of total pancreatectomy with postoperative insulin administration which was discontinued, the blood sugar levels elevated rapidly in association with a significant increase of FFA and decrease of PHLA, and then increase of TG ad pre β-LP fraction. Subsequently those animals died in about 7 days, and the marked fatty degeneration of hepatocytes was observed in the group with total pancreatectomy in which postoperative insulin administration was discontinued.In the dogs of extensive resection of the pancreas, increases of TG and FFA were less than in those of total pancretectomy with postoperative insulin adminstration even at the diabetic phase with high blood sugar levels.From these findings, it might be, therefore, said that lipid metabolism was well controlled by a residual small piece of the pancreas in the cases with extensive resection of the pancreas.
- 財団法人 日本消化器病学会の論文