:(5TH REPORT) Effect of Carbon Tetrachloride-Induced liver Injury
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Effect of carbon tetrachloride-induced liver injury on the prostaglandin E2 levels in rat gastric mucosa was investigated. Male Wistrar rate were given carbon tetrachloride twice a week for 10 and 25 weeks. Mucosal prostaglandin E2 was extracted, purified and determined according to the previous report.The levels of mucosal prostaglandin E2 were decreased both in fundus and antrum in rat treated with carbon tetrachloride (10 weeks: 0.66±0.07 μg/g and 1.58±0.90 μg/g, 25 weeks: 0.84±0.18, μg/g and 1.73±0.13, μg/g) compared with controls (1.09±0.08, μg/g and 2.43±0.36, μg/g). Furthermore, 0.2N HCl induced gastric lesions was enhanced in the rats treated with carbon tetrachloride (ulcer index: 12.8±2.0) compared with controls (ulcer index: 2.2±0.7).These results suggest that in rats with CCl4 induced liver damage, decrease of PGE2 in gastric mucosa enhanced 0.2 N Hcl induced gastric lesions.
- 財団法人 日本消化器病学会の論文