SIGNIFICANCE OF LECITHIN-CHOLESTEROL ACYLTRANSFERASE ACTIVITY IN OBSTRUCTIVE JAUNDICE

概要

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Lecithin-cholesterol acyltransferase (LCAT) which is produced in the liver is the esterifying enzyme of free cholesterol in the blood stream. This enzyme activity is known to be frequently disturbed in patients with liver diseases.We have examined serum LCAT activity in conbination with various liver functional tests and serum lipoprotein-X (LP-X) in patients with obstructive jaundice by colorimetric method. Results are as follows.1) Both high LCAT activity and serum total bilirubin level almost paralleled (Parallel phase), when liver function was not deeply disturbed. LP-X was usually positive and serum total cholesterol level was excessibly high in this phase. 2) LCAT activity was gettig low, but serum total bilirubin level remained high (Separate phase), when liver function was greatly damaged. LP-X usually turned to negative and serum total cholesterol level markedly decreased in this phase, in which the patients prognosis was definitely poor.This classification might be accepted not only in obstructive jaundice but in liver cirrhosis or congestive liver.
財団法人日本消化器病学会の論文