Studies on Serum Glycoprotein in Pancreatic Diseases

概要

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The eight components of serum glycoprotein were determined by single radial immunodiffusion method in 28 patients with cancer of the pancreas, 17 patients with chronic pancreatitis, one patient with acute pancreatitis and 53 patients with non-pancreatic diseases with or without cancer.The results of determination of serum glycoprotein were as follows:1) The mean concentration of serum α1-antitrypsin and α1-acid-glycoprotein in patients with cancer of the pancreas was significantly higher than that in patients with chronic pancreatitis. The mean concentration of prealbumin and transferrin was moderately lower, but there was no significant alteration of the other glycoprotein fractions.2) An increase of α1-antitrypsin and α1-acid-glycoprotein fractions, and a decrease of prealbumin and transferrin fractions of the serum in the patients with cancer of the pancreas, liver and biliary tract were noted. These results, however, were not obtained in patients without malignant tumor.3) Increased α1-antitrypsin and α1-acid-glycoprotein, and decreased prealbumin and transferrin returned to the normal limits following clinical improvement of patients.On the basis of these findings, it was suggested that the variations of serum glycoprotein levels might be resulting from neoplastic diseases and their clinical processes.
財団法人日本消化器病学会の論文