Secretin Release of 1-Phenyl-1-Hydroxy-n-Pentane

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概要

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• In order to clarify the mechanism of the secretion of pancreatic juice and bile after the infusion of 1-phenyl-1-hydroxy-n-pentane (PHP) into the duodenum, plasma secretin and gastrin level were measured after PHP administrated orally and infused into duodenum with radioimmunoassay.The following results were obtained.1) Plasma secretin level was elevated in all the human cases after oral administration of PHP 600mg.2) Plasma secretin level was elevated in all the human cases after infusion of PHP 600mg into the duodenum. This elevated degree was the same as or higher than the result after infusion of 1/10N-HCl solution. No particular change was observed on the plasma gastrin level.The above results seem to reveal that the secretory effect of PHP on pancreatic juice is performed through the release of secretin.

• 財団法人 日本消化器病学会の論文

著者

• 関 敦子

  東京大学第3内科

• 松尾 裕

  東京大学第3内科

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• Secretin Release of 1-Phenyl-1-Hydroxy-n-Pentane

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