Experimental study on the correlation between the pancreas and parotid gland:7th report, Light-microscopic and electron-microscipic study of thepancreas of the rats following bilateral ligation of theparotid gland duct

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Light-microscopic and electron-microscopic observations of the pancreas and parotid gland obtained from the rats were performed in total of 110 rats examined at various periods after bilateral ligation of the parotid gland ducts.The following results have been obtained.1. With the light-microscopy, the parotid gland became atrophic immediately after ligation. In the pancreas, an atypical arrangement of the acinar cells as well as a slight hypertrophy of the islets of Langerhans was observed at 4 days to two weeks following ligation.2. Electron-microscopically, in the pancreatic acinar cells the dilatation of the granular endoplasmic reticulum irregularities of the nuclear border and increase of heterochromatin were noticed at 48 hours to 5 weeks following ligation. In the islets of Langerhand, there were observed such changes as a decrease in electron density, swelling of the granules and disintegration and fusion of limiting membranes of granules in the beta cells at 4 days to 5 weeks after ligation. It was speculated that an impairment of the parotid glands influenced on the pancreas to a certain degree.
財団法人日本消化器病学会の論文