An Experimental Study on Gastric Hypersecretion after Ligation of Pancreatic Duct:The Changes of Serum Gastrin Levels
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The present study was performed to investigate gastric secretion and serum gastrin levelsafter ligation of the pancreatic duct in Heidenhain pouch dogs.The results obtained were summarized as follows:Serum gastrin levels began to elevate from the second week and reached high levels at the fourth week after a complete pancreatic duct ligation. However, the elevation of serum gastrin levels was not markedly after a simple pancreatic duct ligation. Gastric hypersecretion and hypergastrinemia were confirmed by the oral administration of glycine solution in dogs after a complete pancreatic duct ligation. Ulcer was observed in the stomach or Heidenhain pouch by pathological examination. Glycine-induced gastric hypersecretion and hypergastrinemia could be inhibited by intravenous injection of glucagon.These results suggested that the origin of oversecreted gastrin after a complete pancreatic duct ligation was mainly from the gastric antrum.
- 財団法人 日本消化器病学会の論文
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