Studies on the relationship between endocrine and exocrine pancreatic functions:Part II Exocrine pancreatic function and insulin and glucagon levels in streptozotocin induced diabetic rats
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概要
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Exocrine pancreatic function with pancreozymin or secretin loading test and changes of insulin and glucagon levels were studied in streptozotocin induced diabetic rats.The results obtained were as follows:1. A remarkable and significant decrease of amylase output was observed in diabetic rats. An improvement of amylase output was achieved by the administration of insulin.2. A moderate decrease of immunoreactive insulin(I) level was indicated in diabetic rats, however, immunoreactive glucagon(G) level revealed no changes. The molar ratio in G/I was higher in diabetic rats than in control rats. A significant elevation of glucagon level, on the other hand, was shown after intravenous injection of arginine to diabetic rats.In conclusion, pancreatic exocrine dysfunction observed in streptozotocin induced diabetic rats was also attributed to a diminution of insulin and concomitant elevation of G/I molar ratio. These findings would support the clinical findings indicated previouly.
- 財団法人 日本消化器病学会の論文