Effect of Transection at the Antral-Fundic Junction on Secretion of Serum Gastrin and Heidenhain Pouch Acid After Feeding

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The effect of transection at the antral-fundic junction with or without antral vagotomywas studied on the secretion of serum gastrin and acid from the Heidenhain pouches, using8 dogs.The results are as follows:1) In fasting and feeding, transection without antral vagotomy produced a moderateincrease in serum gastrin concentration and a decrease in acid secretion from the pouches.2) In fasting and feeding, transection with antral vagotomy produced a significantincrease in serum gastrin concentration and a marked decrease in acid secretion fromthe pouches.3) With respect to the variation with time, there was observed a delay of acid secretoryresponse to a meal in the case of transection with antral vagotomy.These findings suggested that transection at the antral-fundic junction with the divisionof the extrinsic and intrinsic innervation might lead to an increase in serum gastrin concentrationand a decrease in acid secretion from the Heidenhain pouches, and there was no obviouscorrelation between serum gastrin concentration and acid secretion from the Heidenhainpouches on stimnlatiou by feeding.
財団法人日本消化器病学会の論文