75Se-Radioactivity in Duodenal Aspirate as a New Clinical Test for Pancreatic Exocrine Function:Radioselenium Pancreozymin-Secretin Test
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概要
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The appearance of radioselenium in the protein fraction of duodenal aspirates hasbeen studied after an intravenous injection of 75Se-selenomethionine, and a new clinical testfor pancreatic exocrine function; the radioselenium pancreozymin-secretin test, hasbeen developed.The continuous flow of pancreatic juice was stimulated by pancreozymin at 120 minutesand by secretin at 140 minutes, and 75Se-radioactivities in duodenal aspirates were analyzed.A good distinction between normal subjects and patients with suspected pancreatic diseasesas well as pancreatic diseases was obtained by measuring 75Se-radioactivity in the proteinfraction of duodenal aspirates; either cumulative radioactivity during the combined 80-minute postpancreozymin-secretin period, or maximum 75Se-specific activity during thepostsecretin period was used as an index.The test presented here might be a useful and sufficiently reliable method for detectingabnormal pancreatic exocrine function.
- 財団法人 日本消化器病学会の論文