HEPATIC ADENOSINE TRIPHOSPHATE LEVELS IN ETHIONINE-TREATED RATS AFTER INTRADUODENAL ADMINISTRATION OF ADENOSINE TRIPHOSPHATE
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概要
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Hepatic ATP-deficiency induced by ethionine in female rats was restored by intraduodenal administration of ATP in a dose of 2m mol/kg. Administration of ADP was somewhat effective but that of AMP, adenosine and inosine which were well-known as a precursor for ATP-synthesis could not restore hepatic ATP-deficiency in the same dose. Administration of [8-14C] ATP through the duodenum of a male rat resulted in incorporation of larger amount of radioactivity into hepatic ATP-pool than that after administration of [8-14C] AMP or [8-14C] adenosine. Main metabolites of portal plasma after the administration of ATP were determined to be AMP and inosine by means of ionexchange column chromatography but a metabolite, in both cases of the administration of AMP and adenosine, was uric acid only. The results may indicate the utilization of intraduodenally administered ATP for ATP-synthesis not only in the liver damaged by ethionine but also in normal liver.
- 財団法人 日本消化器病学会の論文