EXPERIMENTAL CARCINOMA OF THE CANINE BILIARY TRACT INDUCED BY N-ETHYL-N'-NITRO-N-NITROSOGUANIDINE

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概要

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• In order to produce experimental carcinoma of the canine biliary tract, 5-10ml of 0.7-1.0mg/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered through tube cholecystostomy every day for a maximum period of 180 days in 18 mongrel dogs.Carcinomas of the bile duct developed in all of 7 dogs which survived more than 345 days after the start of the ENNG administration. Most of these carcinomas developed in the common bile duct and had a tendency of developing in multiplicity. Histological type of the carcinoma was papillary or tubular adenocarcinoma, with high incidence of neural invasion in the duct wall.The mode of development of these carcinomas could be divided into 2 types: 1) polypoid type, projecting into the bile duct lumen, and 2) infiltrating type, invading deeply into the bile duct wall. As for the histogenesis of the carcinomas, the polypoid type appeared to originate from adenomas, while the infiltrating type develop as de novo cancer.

• 財団法人 日本消化器病学会の論文

著者

• 市川 正章

  名古屋大学医学部第2内科

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