STUDIES ON ABNORMAL LIPID METABOLISM IN CHOLESTASIS, WITH SPECIAL:REFERENCE TO OCCURRENCE OF LIPOPROTEIN-X (LP-X)
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概要
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In order to clartify abnormalities of lipid metabolism in patients with cholestasis, plasma lipids and lipoproteins were analyzed by various methods such as electrophoresis, gel filtration, electron microscopic examinations, and analytical ultracentrifugation.Lipid analysis revealed enhancements of phospholipid, free cholesterol and triglyceride, whereas cholesterol ester ratio and phospholipid/free cholesterol ratio were decreased. Lipoprotein analysis showed the presence of a distinct lipoprotein in plasma. Immunological and ultracentrifugal studies disclosed that the special lipoprotein was identical with Lp-X, isolated by Seidel's method.Most of the changes observed in both lipids and lipoproteins in plasma of patients with cholestasis can be explained by the presence of abnormal Lp-X. On the other hand, several other changes of plasma lipoproteins and lipids, such as reduction (or absence) of either α-or pre-β lipoprotein, as well as elevation of triglyceride, are not due to the consequences of elevated Lp-X.In cholestatic plasma, major portion of triglyceride was found to be in LDL fraction rather than in VLDL fraction, indicating the abnormality in LDL fraction, the Sf coefficient of which was significantly higher than that of plasma LDL in normal subjects.Fatty acid analysis of lecithin and cholesterol ester of isolated Lp-X showed that both lipids were originated from the bile, since their fatty acid compositions were similar to those of bile lipids, but neither to those of normal plasma nor chylomicron.
- 財団法人 日本消化器病学会の論文