AFP PRODUCING CELLS DURING LIVER RESTITUTION AFTER ACUTE GALACTOSAMINE HEPATITIS IN THE RAT:Immunoperoxidase and Autoradiographic Studies

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概要

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• This study was designed to determine AFP producing cells during restitution of acute rat hepatitis induced by galactosamine administration. When galactosamine was given to animals intraperitoneally, liver restitution was first seen after 3 days. AFP positive hepatocytes were detected in an area where regeneration of the damaged liver cells occurred. By concurrent application of immunoperoxidase and autoradiographic methods, it was shown that the AFP positive hepatocytes tended to appear with a little delay from the appearance of the DNA synthesizing hepatocytes. In immunoperoxidase electron microscopy, AFP was demonstratedd in close association with polyribosomes.The present study suggests that AFP in acute galactosamine hepatitis was produced by the regenerating hepatocytes.

• 財団法人 日本消化器病学会の論文

著者

• 野口 武英

  千葉大学病理学教室

関連論文

• AFP PRODUCING CELLS DURING LIVER RESTITUTION AFTER ACUTE GALACTOSAMINE HEPATITIS IN THE RAT:Immunoperoxidase and Autoradiographic Studies

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