EXPERIMENTAL STUDIES ON THE MECHANISM OF EXOCRINE PANCREATIC SECRETION:WITH SPECIAL REFERENCE TO THE MOVEMENT OF LANTHANUM TRACER IN INTERCELLULAR JUNCTIONS OF THE EXOCRINE PANCREAS
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概要
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In an attempt to clarify the transport mechanism of water and electrolytes, intercellular junctions of the canine exocrine pancreas by lanthanum tracer technique were studied ultrastructurally to evaluate the permeability characteristics.By perfusion of the pancreas with solution containing ionic lanthanum as a racer, lanthanum particles were perfectly stopped at the tight junction near the apex of the exocrine cells. However, they permeated into the lumen across the tight junction by stimulation with secretin. The flux of lanthanum particles into the lumen did not occur across the tight junction between the acinar cells, but occured across the tight junction between the acinar cell and the centroacinar cell.
- 財団法人 日本消化器病学会の論文