COMPOSITION OF BILE ACIDS IN CASES WITH VARIOUS GASTROINTESTINAL DISEASES

概要

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It has been widely recognized that the disturbance of absorption in various intestinal disorders are caused by the quantitative and qualitative changes of bile acids contained in intestinal juice. Though several reports have been published regarding the composition of bile acids, the results were controversial particularly when lesions are localized either in terminal ileum or colon. Therefore, the analysis of bile acids composition in the duodenal juice taken by means of the stimulation of caerulein was performed with the newly-deviced technique of gas-liquid chromatography combined with thin-layer chromatography. The cases studied were diffuse ileal disease, blind-loop syndrome, terminal ileal disease, colonic disease and gastrectomy.The following results were obtained. (1) The glycine: taurine ratio was 4.1±1.1 in healthy subjects, whereas a marked elevation was noticed in diffuse ileal disease and blind-loop syndrome, the ratio being 25.5 and 17.2, respectively. In sharp contrast, there was no changes in the ratio in cases of terminal ileal and colonic diseases. (2) Cholic acid: chenodeoxycholic acid:deoxycholic acid: lithocholic acid was 0.8:1:0.4:0.03 in healthy subjects; 0.8:1:3.3:0.3 in cases of blind-loop syndrome. In cases of terminal ileal and colonic diseases, the ratio was 0.8:1:0.04:0.04 and 0.7:1:0.07:0.06, respectively. Namely, the proportion of deoxycholic acid noticeably declined.
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