BIOCHEMICAL CHANGES OF THE SERUM AND MORPHOLOGICAL ALTERATIONS OF THE LIVER IN STRENUOUS EXERCISE

概要

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Male Wister rats (200g weigt) were strenuously exercised in a rotating cage for 2 hours. Immediately after the exercise, there were significant elevations of serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase, serum lactic dehydrogenase and plasma free fatty acids, and decreases of serum alkaline phosphatase, serum glucose and serum triglyceride. Pathologic studies revealed an acidophilic degeneration of the hepatocyte, an appearance of fat droplets and depletion of glycogen contents in the hepatocyte. Under electron microscopy, in addition to occational occurrence of coagulation necrosis of the hepatocyte, changes of the mitochondria, increased smooth surfaced endoplasmic reticulum and fat droplet, and decreased amount of glycogen particle were noted in the hepatocyte. Those changes were also proved by morphometric analysis on those organellar changes in the hepatocyte.It seemed likely that those morphological changes of the liver are closely related with biochemical changes of the serum.
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