Therapeutic Effect of Frequent Injections of GnRH Analogue in a Beagle Dog with Knobbed Acrosome Abnormality of Sperm

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A Beagle dog (3 years old) that ejaculated high percentages (mean ± SE: 29.1 ± 1.2%) of sperm with a knobbed acrosome abnormality and a low number of sperm and also had a low plasma testosterone (T) level was given 10 subcutaneous injections of 1 μg gonadotrophin releasing hormone analogue (GnRH-A) per head at 3-day intervals. The plasma T level and number of sperm increased 12–14 weeks after the first injection. Although the percentages of sperm with knobbed acrosome abnormality did not change after the GnRH-A therapy, number of sperm and percentage of actively motile sperm increased after the therapy and a bitch gave birth to 5 healthy puppies after intravaginal artificial insemination with fresh semen collected 14 weeks after the first injection.