Irrelevance between the Induction of Anti-Campylobacter Humoral Response by a Bacterin and the Lack of Protection against Homologous Challenge in Japanese Jidori Chickens

概要

論文の詳細を見る
On-farm vaccination of chickens against Campylobacter jejuni is considered a potentially effective countermeasure to decrease campylobacteriosis via consumption of contaminated chicken meat, but is not yet available. In this study, two groups of Jidori chicks were immunized subcutaneously with a formalin-killed C. jejuni with 2 different adjuvants. Another chicks served as the unvaccinated control group. Both vaccines induced high levels of anti-Campylobacter IgG, but provided no decrease of bacterial excretion in cecal droppings and of bacterial load in the liver and spleen after oral challenge with 105 CFU of the homologous strain. Further study is needed to address the observed irrelevance and to develop a novel effective vaccine against C. jejuni.