リン脂質の機能 : イノシトールリン脂質代謝とその機能を中心として

概要

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Recent numerous studies have indicated that inositol phospholipids metabolism plays an important role in the signal trasduction of Ca2+ mobilizing hormones. The hydrolysis of phosphatidyl 4, 5-bisphosphate (PIP2) by phospholipase C has been considered to be initial event induced by receptor-activation. Breakdown of PIP2 leads to the formation of 1, 2-diacylglycerol (1, 2-DG) and inositol 1, 4, 5-triphosphate [Ins(1, 4, 5)P3] which apparently serve as intercellular 2nd-messengers 1, 2-DG is known to act as an activator for protein kinase C, and Ins(1, 4, 5)P3, another product, is able to release Ca2+ from intercellular store, which cause Ca2+-dependent enzyme activation. Thus activation of protein kinase C and mobilization of intercellular Ca2+ lead to various cellular response.
社団法人日本油化学会の論文