疎水鎖長の異なるホスファチジルコリンと水分子の相互作用 (第2報) : 層間水の構造と膜物性

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The structural characteristics of a water molecule on the membrane properties of L-α-phosphatidylcholines of different chain lengths were investigated by a differential scanning calorimeter (DSC) and small angle X-ray scattering machine (SAXS). Ten water molecules per L-α-phosphatidylcholine were interposed between the bilayers of lipid molecules in the coagel phase and were independent of n-alkyl chain length. On adding urea to L-α-phosphatid-ylcholine-water systems, some of the interlamella water was converted to free water, and the apparent amount of interlamella water decreased with urea content. Furthermore, urea had effect only on the coagel-to-gel transition (Tgel), and not the gel-to-lamella liquid crystalline transition (Tc).<BR>The thickness of L-α-phosphatidylcholine (d1-dw) and interlamella distance (dw) of-L-α-phospatidylcholine bilayer decreased with increase in water and urea content. The radial distribution functions showed some lamella structural periodisity, which lessened on increasing water and urea content. It is thus evident that the structural characteristics of water molecules significantly determine the properties of the L-α-phosphatidylcholine bilayer.
社団法人日本油化学会の論文