某金属鉱山廃水の生体に及ぼす影響についての実験的研究
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概要
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Endemic occurrences of an unknown bone disease have been often reported recently, which was found in Kumano and Shinbo areas along the river Zintsu in Toyama Prefecture and is called by people“Itai-itai”disease. As a cause of this disease heavy metals such as zinc, cadmium, and lead contained in the river water are suspected, which are discharged to the upper stream of the river Zintsu from a metal mine.The author intended to examine in experimental animals whether the water discharged from that mine could produce the similar symptoms to the Itai-itai disease.The water discharged from the mine was administered to mice and rabbits per orally for about nine months and the following results were obtained.1) Body weight of the mice which were given the discharged water increased more slowly as compared with that of the animals which were given distilled water as a control, while there was no difference of body weight between the rabbits which were given the discharged water and those which were given distilled water as a control.2) Hematologic findings such as number of the blood corpuscles, haemoglobin content and hemogram could not be distinguished between the animals which were given discharged water and the control animals.3) Contents of phosphor and calcium in serum and the activity of alkaline phosphatase in serum were not affected by administration of the discharged water.4) Urinary protein could not be detected by any of the tests of 3% sulfosalicyl acid, 25% trichlor acetic acid and of 25% nitric acid.5) Abnormal changes could not be found microskopically in the tissues of heart, lung, kidney, and spleen.6) Abnormal changes could not be found roentogenologically in bone.
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