解熱鎮痛剤のヒト・リンパ球へ及ぼす細胞遺伝学的影響

概要

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The cytogenetic effects of aspirin and acetaminophen were studied on in vitro human lymphocytes. Cells were exposed to either aspirin (0, 75, 150 and 300μg/ml groups) or acetaminophen (0, 200, 400 and 600μg/ml groups) for the entire 72-hour culture period. Corresponding groups served as the controls.It was found that the mitotic indices decreased as the aspirin and acetaminophen dosages increased. However, the occurrence of anomalies such as polyploidy or aneuploidy was not related to treatment with either drug. In contrast, when compared with the control groups, significant increases in chromatid and isochromatid gaps and breakages were noted for cells treated with both of the drugs. In the case of aspirin, the frequency of chromatid gaps was greater than that of isochromatid gaps, while in the case of acetaminophen, the frequency of the latter accounted for the greater proportion of chromosomal anomalies.Neither changes in preferential sites for gaps or breakage, nor changes in satellite association frequency were observed in cells exposed to either drug.
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