実験的カドミウム中毒による貧血--臓器中鉄,カドミウム量及びVD欠乏との関係
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概要
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Female Wistar rats with an average body weight of 100g were divided into 8 groups according to three levels of vitamin D2 added to their diets (0, 1 and 5IU/100g of food), two levels of cadmium (0 and 10mg/100g of food) and the method-oral or subcutaneous-for administration of cadmium.Rats were exposed to cadmium for 500 days.There was a significant decrease of the iron content in the liver, kidney and femur in rats which had ingested cadmium and in vitamin D-deficient control rats. However in the rats which had been injected cadmium there was no decrease in iron in the liver, and only a slight decrease in iron in the femur and kidney was observed.Significant reductions of hematocrit and hemoglobin were found only in those rats which had received cadmium both orally and subcutaneously, although there was no significant difference for iron concentrations in organs between rats having ingested cadmium and rats receiving it both orally and subcutaneously.These results indicate that cadmium-induced anemia can not explained merely as an iron deficiency caused by the oral exposure to cadmium.