騒音暴露による副腎皮質系反応の人とラットとの差異

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This study was undertaken to consider the species specificity of the effects of exposure to noise on adrenal function by applying the findings of experiments on animals to the case of human responses.Humans and rats were exposed to a wide octave-band noise under different conditions of intensity and time, either continuously or intermittently. Under control conditions, the intensity of noise was 30dB (A).In the experiment using rats, subjects were exposed to continuous noise at intensities of 60, 80 and 100dB (C) for 1 hour. Then, a time-series analysis of the 11-Hydroxycorticosterone (11-OHCS) concentration in the adrenal gland were carried out. Intermittent noise was administered at an intensity of 100dB (C) in ON-time and at 52dB (C) in OFF-time for 2 hours at 2, 6, or 20-seconds cycles, and the ratio of noise to pause was 1:1. Then, a time-series analysis of the 11-OHCS concentration in blood serum and the adrenal gland were carried out.In the experiment using humans, subjects were exposed to continuous noise at intensities of 60, 80 and 100dB (C) for 1.5 hours. Intermittent noise was administered at 2-seconds cycle for 1.5 hours in the same manner as in the animal experiment. On both the exposures, time-series analyse of 11-OHCS in blood serum and urine were carried out.The following results were obtained:1) In rats, 11-OHCS concentrations in the adrenal were elevated in both the cases of continuous and intermittent exposure except in the case of intermittent exposure of 2-seconds cycles. The 11-OHCS concentrations in blood sera were elevated for all the exposures. These elevations were remarkable at the initial stage of exposure, although elevation levels were higher for cases of continuous exposure than for those of intermittent exposure.2) In humans, no changes in the 11-OHCS excretion found in urine and in blood serum were observed under either the continuous and intermittent exposure.From the above results, acceleration of adrenocortical function due to exposure to noise can be observed in rats but not in human beings. Thus, the reaction can be said to be species specific.
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騒音暴露による副腎皮質系反応の人とラットとの差異

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