諸種化学物質の環境汚染を通じての人体影響に関する研究-2-数種の魚類易蓄積性化学物質の哺乳動物への蓄積性に関する研究
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概要
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The residualibility of following five chemical products in mammals: 2, 6-di-tert-butyl hydroxy toluene (BHT), para-Dichlorobenzene (DCB), 1, 3, 5-Trichlorobenzene (TCB), Hexachlorobenzene (HCB) and 2, 2', 3, 3'-Tetrachloro diamino diphenyl methane (TCDAM) is reported. These substances are easily accumulated in fish, and are difficult for bacteria to decompose. The experimental results of the absorption, decrease and accumulation rates in mice are reported.Quick, simple and convenient methods of measuring samples from living bodies were established with Gas chromatography and Gas chromatography-mass spectrometry.The gastrointestinal absorption rate of BHT was very low (2.0±0.2%). BHT decreased to 27±3.0% of the dose within 24 hours, and its accumulation rate was about 0.02% of the total dose. There was no difference in the accumulation rate of BHT between mice administered a fish-meal diet of BHT accumulated in gold-fish and others given a diet with BHT added directly.The absorption rates of DCB and TCB were, respectively 11±2.9% and 50±7.8%. But both decrease rates were very fast. Neither DCB nor TCB accumulated within 35 days when orally administered to mice.The gastrointestinal absorption rate of HCB was 38±3.3% and decrease rate was slower than the rates for DCB and TCB. The amounts accumulated agreed with the theoretical values.The absorption rate of TCDAM was 8.0±1.7% and its decrease rate was rapid. No TCDAM was accumulated when orally administered to mice.These five chemical products were difficult for bacteria to decompose, and they were easily accumulated in fish. However, some products were easily metabolized and were not accumulated in mammals. When discussing the effects of these chemical products on health, it is necessary to understand the accumulation factor in mammals.
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