S-methylcysteine sulfoxideの栄養学的価置に関する研究-3-S-methylcysteime sulfoxide(Methiin)及び関連含流アミノ酸,(Alliin,methionine,S-methylcysteine,cysteine)投与のラッテに及ぼす影響
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(1) The effect of S-methylcysteine sulfoxide (Methiin) on anemia and splenic hypertrophy was compared with that of other sulfur containing amino acids. Male Wistar rats were separated into five groups of six each. Group A was fed a basal diet; group B, a 1% Methiin supplemented diet; group C, a 1% methionine-supplemented diet; group D, a 1% cysteine-supplemented diet and group E, a 1% S-methylcysteine (SMC)-supplemented diet. Diet were given ad libitum for 67 days. Spleen weight increased and significant anemia developed in rats fed Methiin, methionine and SMC-supplemented diet. No significant changes were observed in the cysteine-fed rats.(2) Similar experiments were repeated with a restricted diet and 4% levels of sulfur-containing amino acids. Addition of excessive doses of sulfur-containing amino acids resulted in a decrease of body weight in the early stages of the dietary regimens, after which growth gradually increased. Splenic hypertrophy as well as anemia were observed in the Methiin, methionine and SMC-supplemented groups; however the cysteine-supplemented group was normal.(3) To compare the effect of S-allylcysteine sulfoxide (Alliin) and Methiin, rats were separated into four groups of five animals each and the following synthetic diets were given as restricted diets for 21 days. Group A, a basal diet; group B, a 2% Methiin-supplemented diet; group C, a 2% Alliin-supplemented diet; group D, a 2% methionine-supplemented diet. In the Methiin- and methionine-supplemented rats, the spleen weight increased markedly, while rats on the Alliin-supplemented diet showed no such effect. A decrease of red blood cells, hemoglobin and hematocrit was also observed in the Methiin and methionine groups, while no anemia developed in the rats fed Alliin.
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