有機鉛化合物の吸収および排泄に関する研究 : その2. 4メチル鉛, 混合アルキル鉛の吸収, 排泄について

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The relationship between absorption and excretion of tetramethylled and mixed alkyl lead was studied on rabbits. Tetramethyllead was given subcutaneously 14mg (as Pb, diluted with olive oill) every other day for 15 days and mixed alkyl lead was given 15mg every other day for 19 days.In this study the transition of lead concentrations in blood, urine and feces was determined. Tissue distribution after eight or ten weeks lead administration was also determined.Results of experiments are summerized as follows:1) The increase of lead concentrations in blood was very rapid. After discontinuance of lead administration, it decreased very rapidly.2) Excretion of lead increased rapidly in urine, but it was somewhat slow in feces. There was always more lead in feces than in urine.3) About the lead amounts in tissues, there was more in the liver and kidneys, and less in the spleen and bones in comparison to other tissues.4) The excretion of coproporphyrin in urine was lower in tetramethyllead groups than in mixed alkyl lead groups.5) It was thought that tetramethylled and mixed alkyl lead have similar effect on blood. However, their affinity to various tissues may be different.
日本衛生学会の論文