慢性鉛中毒の実験的研究 -Fanconi症候群との関係について-

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Some albino rats were divided according to weight into two groups. One composed those of about 50 grams and the other of about 150 grams. These two groups were fed two different amounts of calcium and lead. The amount of calcium was mixed in food, a little in one and much in the other. Lead was mixed 5mg. and 50mg. per 100 grams in each lot. Thus, for six months they were observed. Aminoaciduria was found in the rats which were given lead. Urinary calcium levels of the rats which were given lead was higher than that of the control in 30 days and in 60 days. In 140 days, however, no difference in urinary calcium level was found. Urinary phosphorus levels of the rats which were given lead and insufficient calcium was higher than that of the control in 30 days. Glycosuria was observed in 60 days in the rats which were given an insufficient amount of calcium and a large amount of lead. No significant changes in serum calcium level, serum phosphorus level and serum alkaline phosphatase level were demonstrated between the lead administered group and control group in 170 days. Concerning rats which were administered lead; in the kidneys the most significant microscopical findings were observed in the tubules, especially in the group which were administered insufficient calcium. As to bone changes, it was found that some rats which were given insufficient calcium and high degree of lead had osteomalacia, but in the case of the group which was given sufficient calcium and lead, significant findings were not apparent. The ratio of Ca divided by P contained in bones of the group given high degree of lead was lower than that of the control group.It was confirmed that the Fanconi syndrom was caused by an oral administration of lead in the state of insufficiency of calcium at early stages.
日本衛生学会の論文

慢性鉛中毒の実験的研究 -Fanconi症候群との関係について-

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