メチル水銀化合物の生体内の動態に関する研究 (総水銀の微量定量法ならびにメチル水銀化合物の生体内の動態に関する研究-1,2-)

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A considerable number of reports have been published on the experimental symptoms of poisoning by mercury. There have however been very few reports on its behaviour in living bodies when the administrated dose was low.In this paper, some information was obtained at a low concentration of administration---information on absorption, excretion, and accumulation of methyl mercury in living bodies using mice of d.d strain, transformation into fetus using rats of Wisterstrain.Results are as follows;1) Absorption rates from the digestive tract of orally administrated mercury compounds were Methyl mercury choloride (MMC) 73%, Phenyl mercury acetate 45% and Mercury acetate 6% after about 6hrs.2) Accumulation in the bodies of mice given solid foods containing MMC 1.0ppm (mercury equivalent) showed apparent increase. But experiments revealed that there was a certain limiting value in accumulation after about 75 days, the value being about 40μg.3) 23.2% of the total administrated MMC dose taken into the mother body passed into the fetus group. MMC concentrations in brain and liver were higher in the fetus-body than in those of the mothers.4) Contents of mercury in blood and hair apparently showed lower values in pregnant rats than in the non-pregnant.5) In comparison with human mother and their new-borns, mercury content in blood corpuscles was higher and that of serum was lower in the new-born.
日本衛生学会の論文