栄養状態がラット脳内トリプトファン,セロトニンおよび5-ヒドロキシインドール酢酸におよぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Effects of nutritional status on the levels of tryptophan (Trp), serotonin (5HT), and its metabolite, 5-hydroxyindoleacetic acid (5HIAA) in six brain regions of rats were investigated.1) A low-protein high-carbohydrate diet decreased Trp, 5HT and 5HIAA levels in the cortex and hippocampus, and those of 5HT and 5HIAA in the hypothalamus. This diet did not affect the contents of Trp and 5HT in the midbrain, but decreased 5HIAA. No significant changes of Trp, 5HT and 5HIAA were observed in the pons and medulla and striatum.2) A low-carbohydrate high-protein diet increased the levels of Trp, 5HT and 5HIAA in the striatum, and 5HT and 5HIAA in the cortex, but showed no effect on the contents of Trp, 5HT and 5HIAA in the hippocampus, midbrain, pons and medulla and hypothalamus.3) An energy-restriction low-carbohydrate diet increased Trp, 5HT and 5HIAA contents in the striatum, and 5HT and 5HIAA in the cortex and pons and medulla. In the hypothalamus, only 5HIAA was increased by this diet. The diet did not influence Trp, 5HT and 5HIAA contents of the midbrain and hippocampus.These results suggest that i) lowered fat and carbohydrate intakes enhance 5HT synthesis and metabolism in the cortex and that lowered carbohydrate intake enhances them in the striatum, ii) energy restriction enhances the 5HT metabolism in the cortex, pons and medulla and hypothalamus, and 5HT synthesis in the cortex and pons and medulla, iii) lowered protein intake inhibits 5HT metabolism in the cortex, midbrain, hippocampus and hypothalamus, and 5HT synthesis in the cortex, hippocampus and hypothalamus.
- 日本衛生学会の論文
著者
関連論文
- 11.四塩化炭素とクロロホルムの肝障害に対する相互作用およびアルコールの影響(一般演題,第33回北陸甲信越地方会)
- 625 四塩化炭素とクロロホルムの肝障害に対する相互作用及びエタノールの影響(有機溶剤,一般演題,第64回日本産業衛生学会・第50回日本産業医協議会)
- 722 尿中トルエン代謝物質の排泄動態とエタノール、フェノバルビタールの影響(有機溶剤,一般演題,第63回日本産業衛生学会・第48回日本産業医協議会)
- ラット脳内ノルアドレナリン,ドーパミン,セロトニンおよびその代謝産物に及ぼす低糖質食とエタノールの影響
- 栄養状態がラット脳内トリプトファン,セロトニンおよび5-ヒドロキシインドール酢酸におよぼす影響