THE CHANGES OF NASAL MUCOSA WITH SEX AND AGE:MEASURING BY METHACHOLINE INHALATION TEST

概要

論文の詳細を見る
Hyperresponsiveness of the nasal mucosa seems to be consisted of sensitivity and reactivity. These two factors can be analyzed by means of Asthograph. We investigated the difference and the change of hyperresponsiveness of the nasal mucosa by sex and age. In patients with allergic and vasomotor rhinitis over 20 years of age, we examined the nasal hyperresponsiveness by directly-writing the dose-response curve of respiratory resistance through the nose during the continuous inhalation of methacholine. Three parameters were obtained from the dose-response curve as follows: initial nasal respiratory resistance (Rrs. N. cont), indicator for the sensitivity of the nasal mucosa (Dmim), and indicator for the nasal reactivity (Sd). Dmin and Sd were significantly correlated to age when logarithmically transformed and Rrs. N. cont was not correlated to age. Dmin became larger and Sd became smaller by aging. The significant sex-difference was observed in thirties for Dmin and Sd.<BR>In this study, we obtained the result that the hyperresponsiveness of the nasal mucosa decreased with age. There was the sex-difference for nasal hyperresponsiveness in thirties.
社団法人日本耳鼻咽喉科学会の論文