鉤虫の感染経路に関する研究 : 特に経皮感染実験について
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概要
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Experiments were carried out on 7 volunteers who had not been infected by hookworms for several years in order, to study the problem of the infection mode of hookworm.Larvae of Ancylostoma duodenale (A.d.) were placed in the center of both palms of 4 volunteers at 20-27°C and the larvae of Necator Americanus (N.a.) were placed in the center of the right palm of 3 volunteers at 26°C.The results were as follows.1) The degree of percutaneous penetration of larvae was 17.9-42.9% with 29.8% as the average in A.d. and 27.3-46.9% with 38.1% as the average in N.a.2) Dermatitis caused by A.d. larvae had symptoms of itching and formication and redness, papules, crusting etc. in 3 cases, and only slight itching in one case. In the case of N.a. slight itching in all cases, and slight redness in one case.3) Hookworm infection was attended by subjective symptoms as follows. 2 cases in A.d. had coughs, expectoration and hoarse voices and a soft stool in one case.4) There was an increase in leukocyte counts and the number of eosinophile cell in 2 cases infected by A.d.5) Ancylosotoma eggs began to appear in the stool of 2 cases in 72 days and 78 days after infection respectively, and for Necator eggs after 80 days in one case.6) 2 cases in 4 were infected by A.d.. The recovering rate of the worm was 8.2% and 35.2%. One case in 3 was infected by N.a. and the recovering rate of the worm was 10.3%.7) These experiments which have been performed for the first time revealed that infection of hookworms can also be made through the palms.
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