Tocilizumab Improved both Clinical and Laboratory Manifestations Except for Interleukin-18 in a Case of Multiple Drug-Resistant Adult-Onset Stills Disease
スポンサーリンク
概要
- 論文の詳細を見る
A patient with adult-onset Stills disease (AOSD) resistant to multiple drugs was treated in our hospital. Even biologics that block tumor necrosis factor (TNF) were ineffective. However, this patient responded quite well to tocilizumab, an interleukin (IL)-6 receptor blocker, suggesting that it is among the promising candidate drugs for multiple-drug resistant AOSD. Although the serum levels of most inflammatory markers such as C-reactive protein (CRP) and ferritin were reduced promptly by tocilizumab, that of IL-18 remained high. Thus, IL-18 is considered to have a further upstream position than IL-6 or to be at the same level as IL-6 in the inflammatory cascade of AOSD. This finding casts light on the pathogenesis of AOSD, and drugs that target IL-18 may prove beneficial in the treatment of this inflammatory disease.
著者
-
Mimura Toshihide
Department Of Rheumatology And Applied Immunology Faculty Of Medicine Saitama Medical University
-
SATO Kojiro
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University
-
Yokota Kazuhiro
Department Of Allergy And Rheumatology Graduate School Of Medicine The University Of Tokyo
-
Yoshida Yoshihiro
Department Of Biochemistry Faculty Of Medicne Kagoshima University
-
Yokota Kazuhiro
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
-
Sakamoto Mayuko
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
-
Mimura Toshihide
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
関連論文
- Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome
- Vasculo-Behcet's disease with non-traumatic subcapsular hematoma of the kidney and aneurysmal dilatations of the celiac and superior mesenteric arteries
- Midkine (MK) Expression in Extraembryonic Tissues, Amniotic Fluid, and Cerebrosphinal Fluid during Mouse Embryogenesis
- Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios
- Efficacy of Cafon gel on cutaneous infection with herpes simplex virus (HSV)-2 and acyclovir-resistant HSV in mice
- Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab
- Tocilizumab Improved both Clinical and Laboratory Manifestations Except for Interleukin-18 in a Case of Multiple Drug-Resistant Adult-Onset Stills Disease
- Th17 Cells and Rheumatoid Arthritis : From the Standpoint of Osteoclast Differentiation
- On 2-dimensional Noetherian semigroups and a principal ideal theorem
- Design Considerations of a Television Camera Detecting Oil Slicks on the Sea
- Social Skills Training for Children
- Serum osteoprotegerin concentration is associated with carotid atherosclerotic plaque in patients with rheumatoid arthritis