A Decrease in the Dose of Pegvisomant was Needed for the Treatment of Acromegaly after Adrenalectomy in a Patient with Coexisting Preclinical Cushings Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
We herein describe the case of a 47-year-old woman with pre-clinical Cushings syndrome caused by a left adrenal adenoma, which was diagnosed 6 years after trans-sphenoidal selective removal of a pituitary adenoma for acromegaly at age 35. The patient was started on bromocriptine and then somatostatin analogues after the surgery; however, since her serum insulin-like growth factor-1 (IGF-1) values remained above the age-adjusted normal range, the treatment for acromegaly was switched from somatostatin analogues to pegvisomant (10 mg daily), before a left laparoscopic adrenalectomy. After the subsequent adrenalectomy, the dose of pegvisomant could be reduced gradually to once every 4 days without any increase in the serum IGF-1 values. This is the first report describing the need for a different dose of pegvisomant for the treatment of acromegaly before and after adrenalectomy for pre-clinical Cushings syndrome.
著者
-
Ogo Atsushi
Department Of Metabolism And Endocrinology Clinical Research Institute National Hospital Organizatio
-
Hiramatsu Shinsuke
Department Of Cardiology Kitasato University School Of Medicine
-
Matsuda Yayoi
Department Of Medicine And Bioregulatory Science Graduate School Of Medical Science Kyushu University
-
Matoba Yuka
Department Of Metabolism And Endocrinology Clinical Research Institute National Hospital Organization Kyushu Medical Center
-
Matoba Yuka
Department of Metabolism and Endocrinology, National Hospital Organization, Kyushu Medical Center, Japan
-
Hiramatsu Shinsuke
Department of Metabolism and Endocrinology, National Hospital Organization, Kyushu Medical Center, Japan
関連論文
- NO SPECIFIC ORGAN REMOVES ATRIAL NATRIURETIC PEPTIDE FROM THE HUMAN PLASMA
- -445- CLINICAL EVALUATION ON THE RESPONSE OF PLASMA ATRIAL NATRIURETIC PEPTIDE TO EXERCISE IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
- -85- VASODILATOR THERAPY FOR RIGHT VENTRICULAR FAILURE OF ACUTE MYOCARDIAL INFARCTION : Congestive Heart Failure : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Autopsy of a Patient with Cushing's Syndrome Who Was Revealed to Have Pulmonary Tumorlets Producing Ectopic ACTH
- Analysis of treatment outcome for lens culinaris agglutinin-reactive alpha-fetoprotein-positive hepatocellular carcinoma in relation to post-treatment disappearance of protein
- Investigation of different methods, particularly percutaneous ablation therapy, for treating non-B, non-C hepatocellular carcinoma
- A Decrease in the Dose of Pegvisomant was Needed for the Treatment of Acromegaly after Adrenalectomy in a Patient with Coexisting Preclinical Cushings Syndrome
- Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia
- A case of fulminant type 1 diabetes mellitus accompanied by myocarditis
- A case of type 2 diabetes with polymyalgia rheumatica accompanied by marked prothrombin time-international normalized ratio elongation
- Pheochromocytoma crisis caused by Campylobacter fetus
- Short-Term Effects of β-adrenergic Antagonists and Methimazole in New-Onset Thyrotoxicosis Caused by Graves' Disease
- Long-term study of subclinical Cushing's syndrome shows high prevalence of extra-adrenal malignancy in patients with functioning bilateral adrenal tumors
- A Pilot Study to Examine the Management of Asymptomatic Hyperparathyroidism in Japanese Patients in Accordance with the Guidelines for Asymptomatic PHPT Proposed at the Third International Workshop in 2008
- Reduced arterial stiffness in patients with acromegaly : non-invasive assessment by the cardio-ankle vascular index (CAVI)