Synthesis, Cytotoxicities and DNA-Binding Affinities of Benzofuran-3-ols and Their Fused Analogs
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概要
- 論文の詳細を見る
A series of benzofuropyrazoles 2a—i were synthesized in 10—92% from the reaction of 2-aroylbenzofuran-3-ols 1a—i with hydrazine hydrate, and screened for their antitumor activities toward four human solid tumor cell lines, including gastric carcinoma cells MKN45, hepatocellular carcinoma cells HepG2, breast cancer cells MCF-7, and lung cancer cells A549. The results indicated that both compounds 1a—i and 2a—i displayed moderate antitumor activities. Among them, compound 2e exhibited potent inhibitory activity toward all the four tumor cell lines. In addition, compounds 1e and 2e showed strong DNA-binding affinities, and induced an increase in the viscosity of calf-thymus DNA, suggesting that they might act as an intercalator.
- 公益社団法人 日本薬学会の論文
著者
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Jiang Zhi-hong
School Of Chinese Medicine Hong Kong Baptist University
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Chen Wen-Hua
School of Pharmaceutical Sciences, Southern Medical University
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Zhou Zhong-Zhen
School of Pharmaceutical Sciences, Southern Medical University
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Zou Min
School of Pharmaceutical Sciences, Southern Medical University
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Zhou Jia
School of Pharmaceutical Sciences, Southern Medical University
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Zhou Chun-Qiong
School of Pharmaceutical Sciences, Southern Medical University
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Deng Yan-Hong
School of Pharmaceutical Sciences, Southern Medical University
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Chen Ming-Hui
School of Pharmaceutical Sciences, Southern Medical University
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Gu Chun-Ping
School of Pharmaceutical Sciences, Southern Medical University
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Liu Shu-Wen
School of Pharmaceutical Sciences, Southern Medical University
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Jiang Zhi-hong
School Of Chinese Medicine Hong Kong Baptist Univ.
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Jiang Zhi-Hong
School of Pharmaceutical Sciences, Southern Medical University
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