FURTHER STUDIES ON THE THYROIDAL CONTROL OF RADIOPHOSPHORUS METABOLISM AS DETERMINED BY THE EFFECTS OF THYROXINE AND PITUITARY EXTRACT ON THIOUREA AND RADIOIODINE TREATED GOLDFISH, CARASSIUS AURATUS L

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Goldfish, Carassius auratus L., were treated with radioiodine and thiourea. In the former the thyroid follicles were completely destroyed, and in the latter they had become hypertrophied and hyperplastic and were devoid of colloid. The follicular cell height had been greatly increased. When they were kept in aquaria with radiophosphorus, the uptake after either type of treatment was similar and it was half of that of the controls. The uptake of P32 in the thiourea treated fish increased by 41.9% after acetone-dried goldfish pituitary gland injections, whereas in radioiodine treated fish there was no significant change. Radioiodine treated fish, when injected with thyroxine, increased their uptake of P32 by 50% but it was even then less than that of the controls. When thiourea treated fish were injected with thyroxine, their P32 uptake was restored to the level of that of the controls. The conclusion drawn from the present investigations is that in fishes, which lack parathyroid glands, the thyroid gland exercises a great influence over the metabolism of phosphorus and that the pituitary gland has also an indirect control through its thyrotrophic hormone.
一般社団法人日本内分泌学会の論文