SERUM INSULIN-LIKE ACTIVITY AND THE EFFECT OF ORAL ANTI-DIABETIC DRUGS WITH SPECIAL REFERENCE TO FAILURE IN LONG-TERM USE

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概要

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• Clinical experience with long-term sulfonylurea treatment has been discussed in the management of diabetes mellitus. Because of the close relationship between fasting serum insulin-like activity and the rate constant for glucose utilization (K) after glucose loading, the latter values were used for screening diabetics in place of the serum insulin-like activity, except for severe diabetics with K value below 0.04. Oral anti-diabetic drugs, such as sulfonylurea, were not effective in diabetics who had no significant extra-insulin secretion reserve. Secondary failure was found to occur more rapidly and more frequently in diabetics with low fasting serum insulin-like activity. In diabetics with low fasting serum insulin-like activity but with relatively high extra-insulin secretion, these drugs were significantly effective and secondary failure developed less rapidly.

• 社団法人 日本内分泌学会の論文

著者

• WADA MASAHISA

  First Department of Medicine, Faculty of Medicine, Osaka University

• SHIGETA YUKIO

  First Department of Medicine, Faculty of Medicine, Osaka University

• Nakamura K.

  First Department of Medicine, Osaka University Medical School

• IZUMI KANJI

  First Department of Medicine, Osaka University Medical School

• WADA MASAHISA

  First Department of Medicine, Osaka University Medical School

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• STUDY ON THE SERUM LEVEL OF THIOCTIC ACID IN PATIENTS WITH VARIOUS DISEASES
• SERUM INSULIN-LIKE ACTIVITY AND THE EFFECT OF ORAL ANTI-DIABETIC DRUGS WITH SPECIAL REFERENCE TO FAILURE IN LONG-TERM USE

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