THE EFFECT OF STEROIDAL DIOSPHENOL AGENTS ON ADVANCED BREAST CANCER

概要

論文の詳細を見る
It is well-known fact that hormonal therapy has been applied to hormonedependent cancer. Androgenic derivatives have been used for long time as an effective agent. The mechanism of anti-tumor action of androgens, however, has not been fully clarified. It is conceivable that there is some discrepancy between the hormonal activity and anti-tumor activity. We tried to find out the steroids having a stronger anti-mammary-tumor activity without hormonal potency. A screening test for anti-tumor activity was performed with a series of diosphenol steroids, and many of them were found to be effective. 2, 17β-Dihydroxy-4, 4-dimethylandrosta-1, 5-dien-3-one was selected as a suitable anti-tumor agent for clinical use because of the highest potency and absense of hormonal side effects. Clinically, 4 out of 20 patients with advanced breast cancer acquired objective remission. The absence of any side effect was confirmed in the clinical trials. The compound is promising for clinical use.
社団法人日本内分泌学会の論文