Effect of Electrical Stimulation of the Brain on Ovulation during Estrous Cycle in the Rats

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The effect of electrical stimulation of the brain on ovulation during estrous cycle in the female Wistar rat was examined by the stimulation of the medial preoptic area using concentric bipolar electrode. Ovulation could be induced 24 hr preceding normal ovulation by the stimulation at the time between 14:00-16:00 on the day of diestrus II. Though the threshold current for induction of ovulation on the day of diestrus II was 5 to 10 times higher than that in the critical period, the numbers of ova in ovulated rats were not significantly different.<BR>The threshold current was gradually decreased from the evening of diestrus II to the morning of proestrus, and showed the lowest value (100-50μA) during the critical period. After the critical period the ovulation was still induced, though the threshold was higher again.<BR>Estrogen (5μg s. c.) injection on the day of diestrus I facilitated ovulation by electrical stimulation at the time between 10:00-12:00 on the day of diestrus II, but not by stimulation at the time between 14:00-16:00.
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