Histochemical Studies of Various Organs in Rats with Experimental Congenital Diabetes
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概要
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Reported here, are the observations on the various histochemical enzyme activities in several organs (pancreas, adrenal glands, thyroid, liver, kidney, and cardiac, diaphragmatic and femoral muscles) and on the histological findings in Langerhans' islets of rats with experimental congenital diabetes (pre-diabetic and diabetic stages) and of offspring born from alloxan diabetic rats in successive generations.<BR>The following results were obtained: a) Histologically, 1) there was a tendency towards hypoplasia of the β-cells (reduced in number and in size) in the Langerhans' islets, which aggravated in the offspring from generation to generation. 2) Degranulation, hydropic degeneration, or atrophy and pyknosis of the β-cells in the Langerhans' islets were noted in rats with spontaneous diabetes. 3) Signs of glycogen nephrosis could be seen in the renal tubules of rats with spontaneous diabetes. b) Histochemically, 1) ACPase activity in the Langerhans' islet cells in the pre-diabetic stage was definitely increased, but markedly decreased in rats with spontaneous diabetes. In the Langerhans' islet cells, G-6-PD activity was also markedly decreased in spontaneous diabetes. 2) ACPase, SD, LD and G-6-PD activities in the fascicular zone of the adrenal cortex were evidently increased in spontaneous diabetes and already somewhat increased in the prediabetic stage. Opposite findings were noted in rats with chronic alloxan diabetes. 3) ACPase and G-6-PD activities were increased in the follicular cells of the thyroid gland in spontaneous diabetes and even somewhat increased in the pre-diabetic stage. 4) ACPase and G-6-Pase activities in the hepatic lobules and SD activity in the renal tubules in spontaneous diabetes were definitely increased. 5) SD and LD activities in the muscular tissues showed a slight increase in the pre-diabetic stage and a marked increase in the diabetic stage.<BR>These experimental results clearly reveal a change from the pre-diabetic stage to the stage of spontaneous diabetes in rats with congenital diabetes experimentally produced, and its study seems to contribute much to the study of human diabetes.
- 社団法人 日本内分泌学会の論文