Changes of Growth Hormone-Containing Cells during Tumorigenesis and Subpassages of Estrogen-Induced Pituitary Tumors in Rats

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The changes of growth hormone-containing cells during the tumorigenesis and subpassages of the estrogen-induced pituitary tumors were studied with peroxidaselabeled antibody method.<BR>In a primary pituitary tumor induced with estrogen in a female W/Fu rat, growth hormone-containing cells were rather small and compressed away by the tumorous growths to localize mainly to the peripheral areas, corresponding with the unchanged acidophils in the routinely stained sections.<BR>The cells positively stained with the peroxidase-labeled antibody were scattered in a transplantable mammotropic pituitary tumor (MtT/F4). Since this tumor is well known to produce growth hormone in addition to prolactin and adrenocorticotropic hormone, a few non-functional growth hormone-containing cells which remained in the primary pituitary tumor were considered to have transformed to secrete growth hormone during the further subpassages.<BR>Further, the changes and variations of the hormonal activities of the estrogeninduced pituitary tumors were discussed from the view point of the different cellular populations.
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