Studies on the Role of the Pituitary Gland in Biosynthesis of Corticosteroid-Binding Globulin in the Male Rat

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The role of the pituitary gland on the biosynthesis of corticosteroid-binding globulin (CBG) was investigated in male albino rats. It took 48 hr after adrenalectomy to record a significant increase in corticosteroid-binding capacity (CBC). Likewise, a significant depression of CBC was observed only beyond 48 hr after the start of 40μg/day of dexamethasone injection. From these findings it may be interpreted that glucocorticoids exert an inhibitory effect physiologically upon CBG synthesis and that adrenalectomy would abolish such an depressive action by the elimination of endogenous corticosteroids. Daily administration of 20μg of estradiol resulted in a significant increase in CBC in 5 days. Furthermore, dexamethasone showed inhibiting completely such a stimulatory effect of estradiol on CBC, which was, in contrast, augumented by adrenalectomy. These results suggested that there might exist a competition for the biosynthesis of CBG between the inhibitory action of glucocorticoid and the stimulatory effect of estradiol.<BR>Hypophysectomy did not interfere with the supressive effect of dexamethasone on CBC but abolished the CBC response to adrenalectomy or estradiol treatment, which could not be restored by replenishment with various pituitary hormones, such as ACTH, RGH, RFSH, BTSH or ovine prolactin as well as pituitary autoimplantation. The present results indicate that either unknown pituitary factor (s) or synergic action of multiple pituitary hormones may be needed only when the biosynthesis of CBG is accelerated and elaborated with a mechanism for which the neural and/or vascular connection between the gland and the hypothalamus is indispensable.
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Studies on the Role of the Pituitary Gland in Biosynthesis of Corticosteroid-Binding Globulin in the Male Rat

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