Demonstration of C-peptide Immunoreactivity in Various Body Fluids and Clinical Evaluation of the Determination of Urinary C-peptide Immunoreactivity

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概要

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• C-peptide immunoreactivity (CPR) was demonstrated not only in plasma, but in urine, ascites, cerebrospinal fluid and pleural effusion.<BR>The concentration of CPR in urine was very high compared with that in the other body fluids and was easy to assay. CPR in urine after glucose administration or tolbutamide injection increased parallel to the change of CPR in plasma and also to that of IRI in normals or diabetics without renal disturbances.<BR>The results suggest that the determination of CPR in urine before and after stimulation of insulin secretion could serve as a simple indicator of insulin secretory function of pancreas.

• 社団法人 日本内分泌学会の論文

著者

• Oda Toshitsugu

  1st Dept. Intern. Med. Univ. Of Tokyo School Of Med.

• Suzuki Seiji

  1st Dept. of Internal Medicine Univ. of Tokyo

• Oka Hiroshi

  1st Dept. of Internal Medicine Univ. of Tokyo

• KANEKO TOSHIO

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

• MUNEMURA MASAHIDE

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

• YASUDA HIROKO

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

• YANAIHARA NOBORU

  The Bioorganic Chemistry, Shizuoka College of Pharmacy

• NAKAGAWA SHINYA

  The Bioorganic Chemistry, Hitachi General Hospital

• MAKABE KAZUO

  The Bioorganic Chemistry, Hitachi General Hospital

• Oka Hiroshi

  1st Dept. Of Intern. Med. Faculty Of Med. Univ. Of Tokyo

• OKA HIROSHI

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

• SUZUKI SEIJI

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

• ODA TOSHITSUGU

  1st Department of Medicine, Faculty of Medicine, University of Tokyo

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• Demonstration of C-peptide Immunoreactivity in Various Body Fluids and Clinical Evaluation of the Determination of Urinary C-peptide Immunoreactivity

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