Inhibitory Effect of Ouabain on Epinephrine-Induced Stimulation of Adrenal Corticosterone Secretion in Rats
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概要
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Chronic administration of ouabain (3mg/Kg body weight, subcutaneously, once daily for consecutive 15 days) definitely inhibited epinephrine-induced increase of adrenal corticosterone secretion. The inhibition rate increased along with frequency of ouabain administration. Increase in adrenal corticosterone synthesis and secretion by ACTH (20-50mU/rat) administration was partially suppressed by pretreatment with chronic ouabain administration. A slight but significant increase of adrenal corticosterone secretion caused by epinephirine administration in hypophysectomized rats was also inhibited by pretreatment with ouabain administration. Chronic administration of neither phentolamine (1mg/rat, intraperitoneally, once daily for consecutive 15 days) nor propranolol (3mg/Kg body weight, subcutaneously, once daily for consecutive 15 days) caused significant changes in adrenal corticosterone secretion in response to ACTH as well as to epinephrine.<BR>Chronic administration of ouabain in rats causes not only elevated secretion of ACTH from anterior pituitary but also functional change in adrenals leading to suppression of corticosterone secretion in response to ACTH or epinephrine administration.
- 社団法人 日本内分泌学会の論文
著者
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INABA Minoru
Division of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University
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KAMATA KUNIE
Division of Bio-Function Research, Biomedical Research Laboratory, Jikei University School of Medici
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INABA MINORU
Division of Bio-Function Research, Biomedical Research Laboratories, Jikei University School of Medicine
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KAMATA KUNIE
Division of Bio-Function Research, Biomedical Research Laboratories, Jikei University School of Medicine
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