The Diurnal Rhythm of Plasma Aldosterone, Plasma Renin Activity, Plasma Cortisol and Serum Growth Hormone and Subnormal Responsiveness of Aldosterone to Angiotensin-II in the Patients with Normotensive Acromegaly

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概要

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• The diurnal rhythm of plasma aldosterone concentration (PA), plasma renin activity (PRA), plasma cortisol (PC) and serum growth hormone (GH) were examined in 5 cases of normotensive acromegaly and the results were compared with the observations in normal subjects. Moreover, the response of PA to angiotensin-II infusion was studied in 6 cases of normotensive acromegaly.<BR>A normal diurnal rhythm with the lowest values in the evening or midnight and the highest values in the morning was observed in 3 of 5 cases in PA and 3 of 4 cases in PC. On the other hand, no apparent rhythm of GH was observed in any cases and that of PRA in 4 of 5 cases. Although there was a significant positive correlation between PA and PC, no significant correlation was demonstrated between PA and PRA. The response of PA to angiotensin-II infusion was significantly suppressed in normotensive acromegaly as compared to the normal subjects in spite of normal levels of PRA except for 1 case.<BR>The above observations were interpreted to suggest that the aldosterone regulation system is slightly altered in a certain number of patients with normotensive acromegaly in contrast to the normal subjects in which PRA is the main contributing factor. The low PA and suppressed response of PA to angiotensin-II infusion may suggest the defective action of angiotensin-II infusion on the adrenal gland.

• 社団法人 日本内分泌学会の論文

著者

• Sakamaki Tetsuo

  2nd Dept. of Internal Med. Gunma University

• Sugai Yoshiro

  2nd Div. Dept Of Intern. Med. Gunma University School Of Med.

• Ichikawa Shuichi

  2nd Department of Internal medicine, Gunma University School of Medicine

• TONOOKA SACHIKO

  2nd Department of Internal Medicine, Gunma University School of Medicine

• SAKAMAKI TETSUO

  2nd Department of Internal Medicine Gunma University School of Medicine

• ICHIKAWA SHUICHI

  2nd Department of Internal Medicine Gunma University School of Medicine

• TONOOKA SACHIKO

  2nd Department of Internal Medicine Gunma University School of Medicine

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