Characterization of Renin-like Activity in Human Plasma Protein IV-4 Fraction
スポンサーリンク
概要
- 論文の詳細を見る
Cohns fraction IV-4 of human plasma protein generates by itself a substance with slight pressor activity when incubated without any additives. This renin-like activity was readily inactivated by alkaline treatment. Furthermore, the generated pressor substance, when purified, was found very similar to [Asp1]-[Ile<SUP>5</SUP>]-angiotensin-I in the following characteristics;1) heat-stability, 2) dializability, 3) inactivation by trypsin, 4) R<SUB>f</SUB> value and 5) electrophoretic mobility at various pHs, 6) marked enhancement in pressor and oxytocic activities after incubation with normal human plasma or rabbits lung extract, and 7) cross reactivity with [Asp1]-[Ile<SUP>5</SUP>]-angiotensin-I in radioimmunossay.<BR>It is concluded that renin-like activity in the preparation of fraction IV-4 of human plasma protein must be renin or an extremely similar enzyme.
- 社団法人 日本内分泌学会の論文
著者
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Arakawa Kikuo
Research Instit. Of Angiocardiol. And Cardiov. Clin. Kyushu Univ. Med. School
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Arakawa Kikuo
Dept. Of Intern. Med. Fukuoka Univ. School Of Med.
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Arakawa Kikuo
Res. Ins. Of Antiocardiol. And Cardiovas. Clin. Kyushu Univ. School Of Med.
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Arakawa Kikuo
2nd Department Of Internal Medicine Fukuoka University School Of Medicine And Department Of Internal
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MINOHARA ATSUSHI
2nd Department of Internal Medicine, Fukuoka University School of Medicine
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UEMURA NOBUHIRO
2nd Department of Internal Medicine, Fukuoka University School of Medicine
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SAKAI TERUO
2nd Department of Internal Medicine, Fukuoka University School of Medicine
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IKEDA MASAHARU
2nd Department of Internal Medicine, Fukuoka University School of Medicine
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