Effect of methallibure (ICI compound, 33, 828) on ovarian activity in the catfish, Heteropneustes fossilis (bloch).

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The effect of methallibure on ovary of <I>H. fossilis</I> was studied. Intraperitoneal administration of methalibure (100μg/g body weight) once a week for 4 weeks was very effective in suppressing the gametogenic and endocrine activities of ovary. The regressed condition of ovary was also apparent in GSI (2.84 to 1.09) readings. This decreased state of activity was further confirmed by reduced ovarian <SUP>32</SUP>P uptake (28.00 to 18.10). The results obtained after the administration of the above compound on ovary were similar to those of surgical hypophysectomy.
社団法人日本内分泌学会の論文