Cytological Changes of the Pituitary Basophils in Rats Slowly Infused with LRH and with LRH and TRH in Combination
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Young male rats were iv infused with synthetic LRH (L) and with L and TRH (T) in combination for 1, 3, 24, 48 and 72 hrs at each dose of 1μg/hr. All the basophils of the controls infused with saline are divided into the continuous cyclic types, <I>i. e</I>., II-, II/III, III-, III/IV- and III/IV/II-types. The II-, III-and III/IV- type cells correspond, infine structure, with those of the classical thyrotrophs, LH- and FSH- gonadotrophs, respectively. A 1-hr infusion of L does not induce any serious changes in all the basophils. After a 3-hr infusion of L, the II-type cells disperse from the gland, while the III/IV-type cells diminished the number of their small secretory granules, and the lumina of endoplasmic reticulum are closed. After a 24-hr infusion, the irregularly shaped III/IV/II-type cells which may revert from the III/IV- to the II-type cells are accumulated, whose secretory granules are remarkably reduced in diameter (50-100nm). There is evidence to show the diffusion mechanism of the secretory granules into the ground matrix. After a 48-hr infusion of L, most basophils take an appearance of III/IV/II-type cells; after a 72-hr infusion, all the basophils show the homologous fine structure. Thus, the morphological changes of the basophils following the L infusion resemble intrinsically those following the T infusion (Soji, 1976b). From these results, it is tentatively concluded that L does not act only on the III-type cells analogous to the “LH-cells”, but universally upon a series of basophils.<BR>The transformations of the III/IV-type cells into the III/IV/II-type ones and those of the II-type ones into the III- or III/IV-typeones due to a slow infusion of L are inhibited to some extent by the infusion of T+L. The granular releases from the III/IV- and II-type cells due to a slow infusion of L are also inhibited to some extent by the infusion of T+L. For this reason, both T and L may act, not synergistically but antagonistically, upon the transformation of a series of basophils and the ir granular release.
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