Sustained hypoglycemia in response to intravenous infusion of D-ribose in normal dogs.

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概要

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• The intravenous infusion of D-ribose to normal, nonanesthetized and anesthetized dogs at a rate of 3mg/kg·min produced a sustained hypoglycemia. The mean blood glucose concentration decreased to a level about 30mg/d<I>l</I> below the fasting level in 45 min after starting D-ribose infusion and remained at the same level until the infusion was discontinued. After stopping the infusion the blood glucose concentration returned to the preinfusion level in about one hour.<BR>The plasma IRI (immunoreactive insulin) concentration in pancreatic effluent blood in anesthetized dogs increased rapidly, peaked within 5-10 min and then declined gradually, but remained above the basal level during the sustained hypoglycemia.<BR>The plasma IRI concentration in pancreatic effluent blood declined further below the basal level after stopping the infusion. In mixed blood an essentially similar pattern in time course of the plasma IRI concentration was observed in both nonanesthetized and anesthetized dogs.<BR>No change in the plasma IRG (immunoreactive glucagon) concentration in pancreatic effluent blood and the plasma CGH (canine growth hormone) concentration in mixed venous blood was observed during or after the infusion of D-ribose.<BR>The invariable occurrence of hyperinsulinemia during the period of progressive fall of blood glucose and sustained hypoglycemia suggests that insulin release is essential for D-ribose-induced hypoglycemia. Glucagon and growth hormone do not seem to play a role in producing a sustained hypoglycemia to prevent further progress of hypoglycemia by increasing their concentration in the blood. The pattern of insulin release during D-ribose infusion suggests the occurrence of the suppression of D-ribose-stimulated insulin release by the fall of blood glucose below the fasting level, which produces a sustained hypoglycemia at a certain level.

• 社団法人 日本内分泌学会の論文

著者

• TSUSHIMA TOSHIO

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• IRIE MINORU

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KUZUYA NOBUSADA

  Department of Endocrinology and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation

• Ishiwata Kazuo

  Department of Endocrinology and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation

• KAJINUMA HIROSHI

  Department of Endocrinology and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation

• HETENY GEZA

  Department of Physiology, Faculty of Medicine, University of Ottawa

• TSUSHIMA TOSHIO

  The Third Department of Internal Medicine, Faculty of Medicine University of Tokyo

• IRIE MINORU

  The Third Department of Internal Medicine, Faculty of Medicine University of Tokyo

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• Sustained hypoglycemia in response to intravenous infusion of D-ribose in normal dogs.

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